ZEBRAFISH IGF GENES: GENE DUPLICATION, CONSERVATION AND DIVERGENCE, AND NOVEL ROLES IN MIDLINE AND NOTOCHORD DEVELOPMENT.

Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development.

Insulin-like growth factors (IGFs) are key regulators of development, growth, and longevity.In most vertebrate species including humans, there is one IGF-1 gene and one IGF-2 gene.Here we report the identification and functional characterization of 4 distinct IGF genes (termed as igf-1a, -1b, -2a, and -2b) in zebrafish.These genes encode 4 structur

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Prospective study of human herpesvirus 8 oral shedding, viremia, and serological status among human immunodeficiency virus seropositive and seronegative individuals in Sao Paulo, Brazil

Human herpesvirus 8 (HHV-8) is a gamma-herpesvirus and etiological agent of all forms of Kaposi sarcoma (KS).Saliva may play an important role in HHV-8 transmission in specific populations.Little is known about HHV-8 oral shedding pattern and the possible correlation with the HHV-8 serological profile and viremia.A prospective study was conducted o

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Accessibility gaps of physical supervised consumption sites in copyright motivating the use of overdose response technology/phone based virtual overdose response services: a retrospective cohort studyResearch in context

Summary: Background: Overdose response technology or virtual overdose response services are an evolving complementary harm reduction intervention which may overcome certain accessibility barriers of physical supervised consumption sites (SCS) and overdose prevention sites (OPS).We sought to characterize SCS/OPS accessibility barriers among clients

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